2,5-Dichloro-6-methoxybenzoic acid
3,6-dichloro-O-anisic acid plant cell*culture tes
CAS: 1918-00-9
Molecular Formula: C8H6Cl2O3
2,5-Dichloro-6-methoxybenzoic acid - Names and Identifiers
2,5-Dichloro-6-methoxybenzoic acid - Physico-chemical Properties
| Molecular Formula | C8H6Cl2O3 |
| Molar Mass | 221.04 |
| Density | 1.57 |
| Melting Point | 112-116 °C (lit.) |
| Boling Point | 316.96°C (rough estimate) |
| Flash Point | 2°C |
| Water Solubility | 50 g/100 mL |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 8.98E-05mmHg at 25°C |
| Appearance | Crystals |
| Color | White |
| Maximum wavelength(λmax) | ['223nm(lit.)'] |
| Merck | 14,3040 |
| BRN | 2453039 |
| pKa | 2.40±0.25(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5000 (estimate) |
| Physical and Chemical Properties | Density 1.57 melting point 87-108°C water-soluble 50g/100 mL |
| Use | It has a significant effect on one-season and multi-season Broad-leaved weeds in wheat, maize and other crops |
2,5-Dichloro-6-methoxybenzoic acid - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36 - Wear suitable protective clothing. S16 - Keep away from sources of ignition. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 2 |
| RTECS | DG7525000 |
| HS Code | 29189900 |
| Toxicity | LD50 orally in rats: 1040 mg/kg (Bailey, White) |
2,5-Dichloro-6-methoxybenzoic acid - Upstream Downstream Industry
2,5-Dichloro-6-methoxybenzoic acid - Nature
Open Data Verified Data
pure white crystals, melting point of 114~116 ℃, flash point of 150 ℃,200 ℃ decomposition, relative density (25 ℃) of 1.57, vapor pressure (100 ℃) was 0.5. Solubility at 25 °c (g/L): ethanol 922, isopropanol 760, acetone 810, toluene 130, dichloromethane 260, dioxane 1180, water 6.5. Storage stability, with antioxidant and hydrolysis resistance.
Last Update：2024-01-02 23:10:35
2,5-Dichloro-6-methoxybenzoic acid - Preparation Method
Open Data Verified Data
1.2.4 a three chlorobenzene with sodium hydroxide methanol solution hydrolysis, the formation of 2,4-= chlorophenol, under pressure and carbon dioxide heating reaction, the formation of 2 a hydroxyl group 3,6-= chlorobenzoic acid, finally with dimethyl sulfate methylation is obtained.
Last Update：2022-01-01 10:13:15
2,5-Dichloro-6-methoxybenzoic acid - Introduction
This standard substance is mainly used for measuring instrument calibration, analytical method evaluation and quality control, as well as the content determination and residue detection of corresponding components in related fields such as food, hygiene, environment and agriculture. It can also be used for value traceability or as a standard liquid reserve solution. It is diluted step by step and configured into various standard solutions for work. 1. Sample Preparation This standard substance is made of dicamba pure with accurate purity and fixed value as raw material, chromatographic methanol as solvent, and accurately configured by weight-volume method. dicamba, English name: Dicamba,CAS number: 1918-00-9 2. traceability and fixed value method. this standard substance takes the configuration value as the standard value, and uses high performance liquid chromatography-diode array detector (HPLC-DAD) to compare this batch of standard substances with quality control control samples to verify the preparation value. By using preparation methods, measurement methods and measuring instruments that meet the requirements of metrological characteristics, the traceability of the value of the standard substance is guaranteed. 3. characteristic value and uncertainty (see certificate) number name standard value (ug/mL) relative expansion uncertainty (%)(k = 2)BW10182 The uncertainty of the standard value of dicamba 1002 in methanol is mainly composed of raw material purity, weighing, constant volume and uniformity, stability and other uncertainty components. 4. uniformity test and stability inspection According to the JJF1343-2012 [General Principles and Statistical Principles of Standard Substance Setting], random sampling of sub-packed samples is carried out, uniformity test of solution concentration is carried out, and stability inspection is carried out. The results show that the standard material has good uniformity and stability. The standard substance is valid for 12 months from the date of setting the value. The development unit will continue to monitor the stability of the standard substance. If the value changes are found during the validity period, the user will be notified in time. 5. packaging, transportation and storage, use and precautions 1. Packaging: This standard substance is packed in borosilicate glass ampoules, about 1.2 mL/branch. When removing or diluting, the pipette quantity shall prevail. 2. Transportation and storage: ice bags should be transported, and extrusion and collision should be avoided during transportation; storage under freezing and dark conditions. 3. Use: Balance at room temperature (20 3 ℃) before unsealing, and shake well. Once the ampoule is opened, it should be used immediately and cannot be used as a standard substance after being fused again.
Last Update：2022-10-16 17:14:41
2,5-Dichloro-6-methoxybenzoic acid - Use
Open Data Verified Data
benzoic acid-based herbicides used as foliar or soil herbicides. It has the effect of internal absorption and conduction, and has significant control effect on annual and perennial broad-leaved weeds. Used for wheat, corn, millet, rice and other gramineous crops to prevent and control the pig, raise the wheat Vine, the cattle, the big nest, the mother, the Xanthium sibiricum, the muscaria, the muscaria, the field, G., Cyprinus carpio intestine, etc. After spraying, the medicament is absorbed by the stem, leaf and root of the weed, and is transmitted up and down through the phloem and xylem, which hinders the normal activity of the plant hormone and makes it die. Because of the narrow grass-killing spectrum of dicamba, the effect on some resistant weeds is not good. It is less safe to wheat and is often mixed with 2-methyl -4 monochloramine salt.
Last Update：2022-01-01 10:13:16
2,5-Dichloro-6-methoxybenzoic acid - Safety
Open Data Verified Data
The oral LD50 of the original drug to rats was 1040mg/kg. It has irritation and corrosive effect on rabbit eyes and moderate irritation on rabbit skin. The subacute percutaneous non-effective dose was 500mg/kg in rabbits, 25mg/kg in rats and 1. 25mg/kg in dogs after 2 years feeding. The teratogenic, carcinogenic and mutagenic effects were not found under the experimental conditions. The LC50 was 28mg/L for rainbow trout and 23mg/L (96h) for green Gill molyfish.
Last Update：2022-01-01 10:13:17
2,5-Dichloro-6-methoxybenzoic acid - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxicity | the original drug has an acute oral LD50 of 1879~2740 mg/kg in rats and an acute percutaneous LD50 of> 2000 mg/kg in rabbits. Acute inhalation of LC50>200 mg/kg in rats. It has irritating and corrosive effects on rabbit eyes and moderate irritation to rabbit skin. Subacute percutaneous non-effective dose of 500 mg/kg in rabbits, 25 mg/kg per day in rats and 1.25 mg/kg per day in dogs after 2 years of feeding. No teratogenic, carcinogenic and mutagenic effects were found under the test conditions. Rainbow trout LC5028mg/L, green gill sunfish 23mg/L (96h). |
| use | benzoic acid herbicides (benzoic acid). It has a systemic conduction effect and has a significant control effect on annual and perennial broad-leaved weeds. It is used for wheat, corn, millet, rice and other gramineous crops to control pig calamity, buckwheat vine, quinoa, cattle chestnut, big nest vegetable, sow lettuce, cocklebur, bosho grass, field convolvulus, prickly cabbage, question Jing, carp intestine, etc. Sprayed after seedlings, the medicine is absorbed through the stems, leaves, and roots of weeds, and is conducted up and down through the phloem and xylem, hindering the normal activities of plant hormones, thereby causing their death. Generally, 48% water solution is 3~4.5mL/100 m2 (active ingredient 1.44~2g/100 m2). Due to the narrow grass killing spectrum of dicamba, it has poor effect on some resistance clutter. It is less safe for wheat and is often mixed with 2,4-drop butyl ester or 2methyl 4 chloride amine salt. Used as a herbicide for plants after germination. It is often mixed with one or more phenoxycarboxylic acid herbicides or other herbicides to form a mixture for weeding cereal fields. It has significant effect on one-season and multi-season broadleaf weeds in wheat, corn and other crops Leaf or soil herbicides are conducted through plant leaves and roots. It is used to control annual and perennial broad-leaved weeds in asparagus, corn, sorghum, wheat, sugar cane and other crop fields, and also to control woody bushes in farming areas. Usually used alone or several phenoxycarboxylic acid herbicides are mixed, and can also be mixed with other types of herbicides. |
| Production method | It is prepared with 1,2, 4-trichlorobenzene, methanol, carbon dichloride and dimethyl sulfate as the main raw materials. 2, 5-dichlorophenol is prepared by the reaction of 1,2, 4-trichlorobenzene and CH3OH/NaOH. Then it reacts with CO2 under a certain pressure to form 2-hydroxy-3, 6-dichlorobenzoic acid, and then reacts with (CH3)2SO4 to synthesize dicamba. |
| category | pesticide |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 1039 mg/kg; Oral-mouse LD50: 1190 mg/kg |
| flammability hazard characteristics | open flame combustible; heated decomposition of toxic chloride gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | sand, dry powder, foam |
| occupational standard | STEL 1 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:11:58
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Raw Materials for 2,5-Dichloro-6-methoxybenzoic acid